SignalChem Biotech & Krishgen Biosystems: Innovative Solutions in Biotech

About SignalChem Biotech Inc.

SignalChem is a Canadian biotech company that develops and produces highly innovative and high-quality recombinant cell signaling products. SignalChem capitalizes on its core expertise in cellular signaling, molecular biology, and protein biochemistry to generate more than 2,000 functional protein products. We established ourselves as the industry leader in producing highly active human recombinant signaling enzymes with the world’s largest catalog of active kinases. We at SignalChem aim to support scientists in academia, pharmaceuticals, and biotech industries worldwide by offering the tools and guidance to advance research and facilitate drug discovery and development.

Featured Products

Kinases – SignalChem is a global leader in Kinase manufacturing. With a portfolio of over 1500 kinases, and more than 3000 citations, SignalChem Kinases have not only helped researchers but also have become a cornerstone in cancer research.SignalChem Kinases are categorized as Protein Kinases, Lipid Kinases, Carbohydrate Kinases and Mutant Kinases.
Tau Proteins – Signalchem manufactures one of the most comprehensive selections of recombinant Tau proteins. Our selection includes Tau isoforms, phospho-Tau, and mutant variants, which demonstrates SignalChem’s drive to provide quality reagents to facilitate research in neurobiology. Tau is essential for microtubule stabilization, assembly, and function in neuronal morphology and axonal transport. Tau can control microtubule stability by phosphorylation and through the various isoforms of the protein.
Epigenetic Enzymes – Epigenetic enzymes are crucial in maintaining key cellular functions by modifying chromatin structures and controlling gene transcription processes. These reversible epigenetic DNA and histone modifications are controlled by important enzymes such as methyltransferases and acetyltransferases. Dysregulation of these enzymes have been observed in myriad human diseases such as cancer. In recent years, epigenetic enzymes have emerged as some of the most promising classes of targets for drug discovery projects and development projects. Scientists at SignalChem have developed a full range of epigenetic enzymes including Histone Deacetylases, Acetyl & Methyltransferases, and Deacetylase & Demethylase Proteins. Our high-quality recombinant epigenetic enzymes and corresponding assay methods are valuable tools. Signalchem is paving the way for the next generation epigenetic basic research and drug discovery targets in this growing field. Histone Deacetylases, Acetyl and Methyltransferases, Deacetylase and Demethylase Proteins. Ubiquitin Enzymes and Proteins, G Proteins, Phosphatases, Proteases, Phosphodiesterases, Antibodies, Signaling Proteins, Transcription Proteins, Cell Cycle Proteins, Assay Buffer and Co factors, Assay Substrates

SignalChem Services – Compound Profiling – The compound selectivity profiling service offered by SignalChem is a cost-effective and convenient approach to the drug discovery continuum with only a two-week turnaround time.
Custom Protein Development – Depending upon your needs, SignalChem will work with you to custom develop the target to your desired specifications within a realistic and suitable timeframe. Our products have been used successfully in various applications, including high-throughput screening, activity assays, binding assays, cell-based assays, protein-protein interaction studies, and structural studies.
Custom Recombinant Antibodies production – Recombinant antibodies (rAbs) are a family of biochemical probes with high specificity, which have gained popularity in life sciences research, diagnostics, and clinical therapy. Unlike traditional monoclonal antibodies (mAbs), rAbs are generated in vitro using synthetic genes and do not require the use or harm to animals during the production process. Due to continuing interest and high demand, rAb sequences are becoming increasingly more available to give researchers a growing library of affinity probe designs from which to choose.